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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Raloxifene hydrochloride, Paclitaxel
Phytochemical Name Raloxifene hydrochloride (PubChem CID: 54900 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Reversing Drug Resistance
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Combination Pair ID: 17
Ref_1
Pair Name Raloxifene hydrochloride, Paclitaxel
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Up-regulation Phosphorylation CDC25C hsa995
Up-regulation Phosphorylation CDK1 hsa983
Up-regulation Phosphorylation BCL2 hsa596
Up-regulation Phosphorylation CDC25C hsa995
Up-regulation Phosphorylation CCNB1 hsa891
In Vitro Model BCaP-37 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0164
Bats-72 Bats-72 was screened from ER- human breast cancer cell line BCap37 by time-stepwise and dose-stepwise increment exposure of paclitaxel as described previously / N.A.
Bads-200 Bads-200 was screened from ER- human breast cancer cell line BCap37 by time-stepwise and dose-stepwise increment exposure of paclitaxel as described previously / N.A.
Result Reversal effects of Raloxifene on paclitaxel resistance in 2 MDR breast cancer cells
03. Reference
No. Title Href
1 Reversal effects of Raloxifene on paclitaxel resistance in 2 MDR breast cancer cells. Cancer Biol Ther. 2015;16(12):1794-801. doi: 10.1080/15384047.2015.1095409. Click
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