Pair Name | Raloxifene hydrochloride, Paclitaxel | ||
Phytochemical Name | Raloxifene hydrochloride (PubChem CID: 54900 ) | ||
Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
Structure of Phytochemical |
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Structure of Anticancer Drug |
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2D
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MOL
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Pair Name | Raloxifene hydrochloride, Paclitaxel | |||
Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
Gene Regulation | Up-regulation | Phosphorylation | BCL2 | hsa596 |
Up-regulation | Phosphorylation | CCNB1 | hsa891 | |
Up-regulation | Phosphorylation | CDC25C | hsa995 | |
Up-regulation | Phosphorylation | CDC25C | hsa995 | |
Up-regulation | Phosphorylation | CDK1 | hsa983 | |
In Vitro Model | BCaP-37 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0164 |
Bats-72 | Bats-72 was screened from ER- human breast cancer cell line BCap37 by time-stepwise and dose-stepwise increment exposure of paclitaxel as described previously | / | N.A. | |
Bads-200 | Bads-200 was screened from ER- human breast cancer cell line BCap37 by time-stepwise and dose-stepwise increment exposure of paclitaxel as described previously | / | N.A. | |
Result | Reversal effects of Raloxifene on paclitaxel resistance in 2 MDR breast cancer cells |
No. | Title | Href |
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1 | Reversal effects of Raloxifene on paclitaxel resistance in 2 MDR breast cancer cells. Cancer Biol Ther. 2015;16(12):1794-801. doi: 10.1080/15384047.2015.1095409. | Click |